Metran Humming Vue

Manufacturer Metran

Piston HFO/IMV Ventilator for Neonatal and Pediatric Patients

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if you have any questions on distribution in overseas market.

HFO ventilation can reduce premature baby and neonate.

HFO ventilation is recognized worldwide as an effective treatment for neonates and premature babies.

Perinatal mortality is affected by many things but ventilation plays a major factor in the hospital treatment. HFO (high frequency ventilation) is a gentle ventilation method that is especially effective for neonates and premature babies. Japan has one of the world’s lowest perinatal mortality rates. One reason is adoption of the latest technology. Metran HFO ventilators are used in nearly 90% of NICUs in Japan and we are glad to be able to contribute to the high level of neonatal care in Japan.


HFO ventilation is gentler to the lungs

HFO ventilation provides sufficient and sustained exchange of gas when the stroke volume is smaller than the anatomical dead space.

HFO pressure waves are sinusoidal and symmetrical with respect to the mean airway pressure (MAP) axis. After passing through the endotracheal tube, the amplitude of the HFO pressure wave falls drastically upon entering the trachea so there is minimal pressure variation at the airway periphery near the pulmonary alveoli.

Compared with continuous mandatory ventilation (CMV), HFO ventilation has much less pressure swing at any MAP and this greatly reduces physical injury to the pulmonary alveoli.



A powerful and precise piston generating oscillation


Humming Vue is a high value, full-featured, flexible pediatric HFO ventilator. Like previous Metran models, Humming Vue is a volume generator ventilator. It produces the precise stroke volume (SV) to obtain a specified amplitude pressure (∆P). SV is similar to tidal volume in conventional ventilation. A fixed SV is guaranteed no matter how the lung compliance changes.

The tidal volume which is delivered by the stroke volume of other ventilators becomes flat after the ventilator reaches a certain power or doesn’t have the power to provide higher tidal volume.


Our piston is precisely controlled to within 13 microns on each stroke, allowing you to set stroke volume with resolution of 0.2ml. This fine control of amplitude enables effective PaCO2 management, which is critical when treating very small babies.

Our system maintains the same HFO Vte even after changing an oxygenation setting such as MAP. Users do not need to readjust other parameters after making a change in one setting. MAP remains stable even when the patient is breathing spontaneously.

So stable MAP and ability to manage PaO2 independently from PaCO2 are key features of Humming Vue.


Caring for neonates from birth through to weaning

Humming Series ventilators are used at top hospitals to enable treatment of the patients throughout their early development. A typical protocol for a low-weight premature baby may include stages such as initial use of SIMV for stabilization and application of surfactant, then HFO to support ventilation with the fragile lungs, then return to SIMV once the lungs gain more compliance, and finally a phase of NIV to prepare the baby for weaning*. All of these ventilation modes are provided by Humming Vue, so there is no need to detube or switch to a different ventilator midway through treatment.

Enhanced conventional modes

In addition to HFO, some of the Humming Vue models have enhanced conventional ventilation modes such as APRV and NIV. All modes support treatment of any case.

A new feature VA (Volume Assured) can support respiration control by prioritizing ventilation volume.

Modes and breath types SIMV: PC, VC, VA A/C: PC, VC, VA APRV
VA (Volume Assured)
In addition to VC or PC, Humming Vue also has VA mode which is volume control ventilation with pressure correction. VA supports respiration control especially when CO2 control is prioritized. 001.PNG
Safety with a variety of settings

Appropriate amplitude and SV

If amplitude is set, the SV is automatically adjusted to maintain that amplitude.

If SV is set, the amplitude changes according to the SV setting. You can confirm the lung condition by changing the amplitude or flow.

Even if ventilation is started or after changing the circuit, safe ventilation is assured with appropriate amplitude and SV.


*There are many factors influencing selection of ventilation mode and settings, and the clinician will choose these based on the condition of the patient. The protocol mentioned here is for illustrative purposes only and is not a recommendation for application in a clinical setting.

Sync+ (Sync Plus)

Sync+ is available for PC-SIMV. When the patient has spontaneous breathing, Sync+ uses PS to support those efforts.

When the patient experiences apnea, mandatory ventilation automatically starts after the respiration rate falls below the setting. Sync+ gives you flexible respiration control, especially in neonatal patients with sudden apnea.


Enhanced non-invasive modes

Humming Vue has improved non-invasive modes to support optimum ventilation, like CPAP, NIV and N-CPAP. High-flow therapy is available with cannulas. Humming Vue provides a variety of respiration control for optimal support of each individual patient.

Other useful features

Trend graphs and logs are time-linked. This enables you to easily access any necessary information. When you switch screens, the same event is clearly displayed in both trend graphs.

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